AdipoUpX™ Human SIRT1 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human SIRT1 Lentiviral Particle (Overexpression) is a powerful, high-titer gene delivery tool specifically designed for the stable overexpression of the human SIRT1 gene. This NAD⁺-dependent deacetylase is a key regulator of metabolic longevity and mitochondrial biogenesis. Genome integration enables the establishment of stable cell lines for investigating its role in lipid oxidation and cellular stress responses. This product is screened through rigorous internal quality control to ensure high efficacy and safety, with functional components that can be flexibly customized to meet diverse experimental needs.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: SIRT1

Full Name: Sirtuin 1

Gene Symbol: SIR2; SIR2L1; SIR2alpha

Gene ID: 23411

RefSeq ID-1: NP_001135970.1

RefSeq ID-2: NM_001142498.1

Summary: SIRT1 encodes a class I sirtuin protein characterized by a conserved catalytic core involved in intracellular regulatory processes. The protein functions as a metabolic sensor linking cellular energy status to transcriptional control, influencing pathways related to lipid utilization, glucose homeostasis, and insulin sensitivity. Multiple splice variants expand its functional versatility in metabolic tissues.

AdipoUpX™ Human SIRT1 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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