AdipoUpX™ Human MFN2 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human MFN2 Lentiviral Particle (Overexpression) is a ready-to-use, high-titer vector particle designed for the stable overexpression of the human MFN2 gene. Mitofusin-2 is vital for studying mitochondrial fusion, ER-mitochondria tethering, and energy efficiency in obese tissues. Genome integration provides a reliable platform for researching mitochondrial dynamics. Comprehensive quality control is performed to ensure product safety, and our modular system allows for the flexible selection of fluorescent labels for precise tracking.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: MFN2

Full Name: Mitofusin 2

Gene Symbol: HSG; MSL; MARF; CMT2A; CPRP1; CMT2A2; HMSN6A; CMT2A2A; CMT2A2B

Gene ID: 9927

RefSeq ID-1: NP_001121132.1

RefSeq ID-2: NM_001127660.2

Summary: MFN2 encodes a protein located in the mitochondrial membrane that facilitates mitochondrial fusion and supports the maintenance of the mitochondrial network. It also plays a role in regulating vascular smooth muscle cell proliferation and may influence obesity-related mechanisms. Mutations in this gene are linked to Charcot-Marie-Tooth disease type 2A2, hereditary motor and sensory neuropathy VI, and early-onset stroke. Two transcript variants producing the same protein have been identified.

AdipoUpX™ Human MFN2 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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