LipoKnoxa™ Human ACACB shRNA Lentiviral Particle (Silencing)

Sub Cat. No.	TargetSeq	Region	Inquiry
V0126XX559-1	ACCTCGTAGATGTGGAATTAA	CDS	Inquiry
V0126XX559-2	CCCGAGAACCTCAAGAAATTA	CDS	Inquiry
V0126XX559-3	TGTCCATCCGAGGCGACTTTA	CDS	Inquiry
V0126XX559-4	Other		Inquiry

Product Overview

Description: LipoKnoxa™ Human ACACB shRNA Lentiviral Particle (Silencing) targets ACACB, regulating fatty acid oxidation. By utilizing high-potency U6-driven shRNA or physiologically refined miR30 architectures, researchers can study energy expenditure. Each viral preparation undergoes total QC verification—covering functional activity and microbial safety checks.

Production Cell Line: HEK293T

Promoter: U6; CMV; EF1α; CAG; UBC

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Comprehensive sequencing and PCR analyses were performed to verify the accurate genomic sequence of all viral preparations.

Sterility Test: Confirmed sterile via rigorous microbial analysis; free of bacterial and fungal contamination.

Mycoplasma Test: Rigorous quality control testing has confirmed the absence of mycoplasma contamination in this viral preparation.

Other QC: Customized supplementary testing and in vitro/in vivo assessments are available to verify post-silencing gene expression and biological functionality, ensuring the viral preparations meet the specific potency requirements of your gene interference project.

Storage: Store at -80°C for long-term preservation. Immediate transfer upon delivery is required to prevent loss of viral activity.

Stability: Shelf life: 6–12 months at -80°C (extended stability up to 2 years). Post-thaw: Stable at 4°C for 2–3 weeks without significant degradation of functional titers.

Shipping Condition: Products are delivered on dry ice to maintain the cold chain. Upon arrival, please ensure the presence of dry ice and transfer the vials immediately to -80°C storage.

Handling Notes: Avoid repeated freeze-thaw cycles. Aliquot into low-protein-binding tubes immediately after receipt to maintain optimal activity. For safety and contamination control, all viral handling must be performed inside a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: We ensure product integrity through rigorous QC, but we do not guarantee results in specific research contexts. Proper storage, handling, and total compliance with biosafety laws and safety protocols remain the sole responsibility of the user.

Target Profile

Gene Name: ACACB

Full Name: Acetyl-CoA carboxylase beta

Gene Symbol: ACC2; ACCB; ACCbeta; HACC275; ACACbeta; ACC-beta

Gene ID: 32

RefSeq ID-1: NP_001084.3

RefSeq ID-2: NM_001093.4

Summary: ACACB encodes the biotin-dependent enzyme Acetyl-CoA carboxylase beta, which is localized to the mitochondrial membrane. It catalyzes the production of malonyl-CoA, the primary inhibitor of fatty acid entry into the mitochondria. By controlling the rate-limiting step of fatty acid oxidation, ACACB serves as a strategic target for enhancing lipid burning and treating metabolic syndrome.

LipoKnoxa™ Human ACACB shRNA Lentiviral Particle (Silencing)

Product Overview

Specification

Target Profile

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