AdipoUpX™ Human RETN Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human RETN Lentiviral Particle (Overexpression) is a high-titer system for the specific and stable expression of the human RETN (Resistin) gene. Stable overexpression of this adipokine enables researchers to study the molecular links between adipose inflammation and systemic insulin resistance. The lentivirus characteristic of genome integration establishes reliable cell models for long-term functional studies. Comprehensive quality control is performed on all viral particle products to ensure both product safety and the highest experimental standards.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: RETN

Full Name: Resistin

Gene Symbol: ADSF; RENT; RSTN; XCP1; FIZZ3; RETN1

Gene ID: 56729

RefSeq ID-1: NP_001180303.1

RefSeq ID-2: NM_001193374.2

Summary: RETN encodes a protein belonging to the resistin-like family, characterized by a unique C-terminal sequence featuring ten conserved cysteine residues. In rodents, the RETN homolog is an adipocyte-secreted hormone proposed to be a critical link between obesity and Type II diabetes by interfering with insulin signaling. In humans, its role is more complex, though it also displays an important antimicrobial function in the skin, actively defending against both Gram-positive and Gram-negative bacteria. Its dual function underscores its involvement in both metabolic balance and innate immunity.

AdipoUpX™ Human RETN Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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