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AdipoUpX™ Human KIDINS220 Lentiviral Particle (Overexpression)

Cat. No.: V1225XX427
Species: Human
Target Gene: KIDINS220
Vector System: Lentiviral
Modulation Type: Overexpression
AdipoUpX™ Human KIDINS220 Lentiviral Particle (Overexpression)
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Product Overview

Description: AdipoUpX™ Human KIDINS220 Lentiviral Particle (Overexpression) is a powerful gene delivery tool specifically designed for the stable overexpression of the human KIDINS220 gene. This protein is essential for neurotrophin signaling and has been linked to severe obesity and developmental delays. Stable integration allows for systematic investigation into downstream MAPK signaling and neuronal survival. All particles undergo rigorous internal quality control validation to ensure reliability for neuro-metabolic research, including thorough sterility and mycoplasma detection.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.
Sterility Test: This product was certified sterile following successful microbial growth analysis.
Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.
Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.
Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.
Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.
Shipping Condition: Our lentivirus viral products are shipped using dry ice.
Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: KIDINS220
Full Name: Kinase D interacting substrate 220
Gene Symbol: ARMS; SINO; VENARG
Gene ID: 57498
RefSeq ID-1: NP_001335661.1
RefSeq ID-2: NM_001348732.2
Summary: KIDINS220 encodes a transmembrane protein predominantly expressed in the nervous system, where it regulates neuronal survival, dendritic differentiation, and synaptic plasticity. The protein serves as a scaffold linking membrane receptors, cytosolic signaling components, and cytoskeletal proteins, facilitating crosstalk between neurotrophin and other intracellular signaling pathways. Mutations or aberrant expression are associated with neuropsychiatric disorders, neurodegenerative diseases, and a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus, and obesity. Alternative splicing results in multiple transcript variants.

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