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AdipoUpX™ Human NPY Lentiviral Particle (Overexpression)

Cat. No.: V1225XX446
Species: Human
Target Gene: NPY
Vector System: Lentiviral
Modulation Type: Overexpression
AdipoUpX™ Human NPY Lentiviral Particle (Overexpression)
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Product Overview

Description: AdipoUpX™ Human NPY Lentiviral Particle (Overexpression) is a ready-to-use, high-titer vector particle designed for the efficient and stable overexpression of the human NPY gene. As the most potent orexigenic peptide in the hypothalamus, its stable integration into the host genome facilitates long-term research into hunger signaling and energy conservation. Every batch is validated through comprehensive quality control (titer, sterility, and mycoplasma testing) to ensure research safety. Our platform offers high flexibility for customizing promoters to suit specific neuronal or endocrine models.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.
Sterility Test: This product was certified sterile following successful microbial growth analysis.
Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.
Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.
Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.
Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.
Shipping Condition: Our lentivirus viral products are shipped using dry ice.
Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: NPY
Full Name: Neuropeptide Y
Gene Symbol: PYY4
Gene ID: 4852
RefSeq ID-1: NP_000896.1
RefSeq ID-2: NM_000905.4
Summary: NPY encodes the Neuropeptide Y, a highly abundant neuropeptide widely distributed throughout the central nervous system. NPY acts through G protein-coupled receptors, influencing a wide array of physiological processes, including cortical excitability, stress response, cardiovascular function, and, most notably, food intake (acting as a potent orexigenic, or appetite-stimulating, signal). Molecularly, NPY binding inhibits adenylyl cyclase, activates MAPK, and regulates intracellular ion channels. A polymorphism in the NPY signal peptide is associated with elevated cholesterol levels, increased alcohol consumption, and may be a risk factor for various metabolic diseases and obesity.

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