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AdipoUpX™ Human TUB Lentiviral Particle (Overexpression)

Cat. No.: V1225XX442
Species: Human
Target Gene: TUB
Vector System: Lentiviral
Modulation Type: Overexpression
AdipoUpX™ Human TUB Lentiviral Particle (Overexpression)
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Mammalian Cell Selection:
Fluorescent Reporters:
Titer:
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Product Overview

Description: AdipoUpX™ Human TUB Lentiviral Particle (Overexpression) is a powerful, high-titer gene delivery tool specifically designed for the long-lasting overexpression of the human TUB gene. As a transcription factor essential for the maintenance of hypothalamic neurons, its stable integration facilitates research into the molecular mechanisms of adult-onset obesity. This product is screened through rigorous internal quality control to ensure high efficacy. Researchers can flexibly choose functional components, such as reporters and promoters, for precise multifunctional tracking and longitudinal studies.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.
Sterility Test: This product was certified sterile following successful microbial growth analysis.
Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.
Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.
Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.
Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.
Shipping Condition: Our lentivirus viral products are shipped using dry ice.
Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: TUB
Full Name: TUB bipartite transcription factor
Gene Symbol: rd5; RDOB
Gene ID: 7275
RefSeq ID-1: NP_003311.2
RefSeq ID-2: NM_003320.4
Summary: TUB encodes a member of the Tubby family of bipartite transcription factors. The protein is suspected to play a significant role in both obesity and sensorineural hearing loss. Studies on the homologous protein in mice suggest that TUB functions as a membrane-bound transcription regulator. It is anchored to the plasma membrane but translocates to the nucleus in response to phosphoinositide hydrolysis. This translocation mechanism allows TUB to regulate gene expression in response to extracellular signals, directly linking membrane dynamics and signal transduction to nuclear processes that influence metabolic health. Two distinct isoforms have been identified.

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