AdipoUpX™ Human ACACB Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human ACACB Lentiviral Particle (Overexpression) is a high-titer system for the specific and stable expression of the human ACACB (ACC2) gene. This enzyme regulates mitochondrial fatty acid oxidation by controlling malonyl-CoA levels, making it a key target for studying energy expenditure. The lentivirus characteristic of genome integration establishes reliable cell models for long-term metabolic studies. Every batch undergoes rigorous internal quality control to ensure both product safety and the reproducibility of results, supported by flexible reporter gene options.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: ACACB

Full Name: Acetyl-CoA carboxylase beta

Gene Symbol: ACC2; ACCB; ACCbeta; HACC275; ACACbeta; ACC-beta

Gene ID: 32

RefSeq ID-1: NP_001084.3

RefSeq ID-2: NM_001093.4

Summary: ACACB encodes the biotin-dependent enzyme Acetyl-CoA carboxylase beta, which is localized to the mitochondrial membrane. It catalyzes the production of malonyl-CoA, the primary inhibitor of fatty acid entry into the mitochondria. By controlling the rate-limiting step of fatty acid oxidation, ACACB serves as a strategic target for enhancing lipid burning and treating metabolic syndrome.

AdipoUpX™ Human ACACB Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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