AdipoUpX™ Human HOGA1 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human HOGA1 Lentiviral Particle (Overexpression) is a high-titer system for the specific and stable expression of the human HOGA1 gene. This mitochondrial enzyme is an ideal tool for studying hydroxyproline metabolism and its emerging roles in metabolic homeostasis. All viral particle products undergo comprehensive quality control to ensure safety and efficacy. Clients can freely customize key functional components, including cell-specific promoters, to match their unique experimental environment, ensuring the highest standards of research reliability.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: HOGA1

Full Name: 4-Hydroxy-2-oxoglutarate aldolase 1

Gene Symbol: HP3; NPL2; DHDPS2; DHDPSL; C10orf65

Gene ID: 112817

RefSeq ID-1: NP_001128142.1

RefSeq ID-2: NM_001134670.2

Summary: HOGA1 encodes a mitochondrial aldolase predominantly expressed in the liver and kidneys. It facilitates the final step of hydroxyproline metabolism by breaking down 4-hydroxyl-2-oxoglutarate into glyoxylate and pyruvate. Mutations in HOGA1 lead to primary hyperoxaluria type III, characterized by the overproduction of oxalate and resulting kidney stones.

AdipoUpX™ Human HOGA1 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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