AdipoUpX™ Human NFKB1 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human NFKB1 Lentiviral Particle (Overexpression) is a high-titer system for the specific and stable expression of the human NFKB1 gene. As a central transcription factor in the inflammatory cascade, its stable overexpression allows for the longitudinal study of low-grade chronic inflammation in adipose tissue. All viral products undergo rigorous internal quality control to ensure reliability and safety. Our customizable platform offers high flexibility, allowing clients to freely select from multiple promoters and fluorescent labels for precise targeted delivery and tracking.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: NFKB1

Full Name: Nuclear factor kappa B subunit 1

Gene Symbol: KBF1; EBP-1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappabeta

Gene ID: 4790

RefSeq ID-1: NP_001158884.1

RefSeq ID-2: NM_001165412.2

Summary: NFKB1 produces a 105 kD precursor that is processed by the proteasome into the active p50 subunit of the NF-kappa-B complex. This transcription factor is a master regulator of the inflammatory response, activated by oxidative stress, cytokines, and pathogens. Dysregulated NF-kappa-B signaling is a hallmark of chronic metabolic inflammation, often bridging the gap between obesity and systemic insulin resistance.

AdipoUpX™ Human NFKB1 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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