AdipoUpX™ Human MC2R MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human MC2R MSCV Particle (Overexpression) provides efficient and stable overexpression of the human MC2R gene, encoding the ACTH receptor. MC2R-mediated signaling regulates glucocorticoid production, which has downstream effects on fat accumulation and metabolic homeostasis. The MSCV retroviral system enables robust expression in stem cells, hematopoietic stem cells, and other mammalian cell lines. Comprehensive QC testing ensures consistency, sterility, and safety.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: MC2R

Full Name: Melanocortin 2 receptor

Gene Symbol: ACTHR

Gene ID: 4158

RefSeq ID-1: NP_000520.1

RefSeq ID-2: NM_000529.2

Summary: MC2R is a G-protein-coupled receptor that is selectively activated by adrenocorticotropic hormone (ACTH). It is a key component of the hypothalamic-pituitary-adrenal (HPA) axis, mediating the release of glucocorticoids like cortisol. Mutations in this receptor can cause familial glucocorticoid deficiency, impacting the body's hormonal response to stress and its overall metabolic regulation.

AdipoUpX™ Human MC2R MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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