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AdipoUpX™ Human MAPK14 Lentiviral Particle (Overexpression)

Cat. No.: V1225XX410
Species: Human
Target Gene: MAPK14
Vector System: Lentiviral
Modulation Type: Overexpression
AdipoUpX™ Human MAPK14 Lentiviral Particle (Overexpression)
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Product Overview

Description: AdipoUpX™ Human MAPK14 Lentiviral Particle (Overexpression) is professionally engineered for the long-lasting, stable overexpression of the human MAPK14 (p38 alpha) gene. This product allows for the systematic investigation of thermogenic activation and the "browning" of white adipocytes. Every batch of this ready-to-use, high-titer product undergoes rigorous internal quality control validation. Our platform features a modular design, offering researchers the ability to flexibly select from multiple promoters and reporter genes for precise tracking.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.
Sterility Test: This product was certified sterile following successful microbial growth analysis.
Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.
Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.
Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.
Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.
Shipping Condition: Our lentivirus viral products are shipped using dry ice.
Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: MAPK14
Full Name: Mitogen-activated protein kinase 14
Gene Symbol: RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA
Gene ID: 1432
RefSeq ID-1: NP_001306.1
RefSeq ID-2: NM_001315.3
Summary: MAPK14 encodes a stress-responsive serine/threonine kinase belonging to the mitogen-activated protein kinase family. Acting as an integration hub for multiple signaling pathways, MAPK14 regulates key cellular processes including proliferation, differentiation, transcriptional control, and development. Activation of this kinase occurs in response to environmental stress and inflammatory cues through MKK-mediated phosphorylation or TAB1-induced autophosphorylation. MAPK14 phosphorylates a broad spectrum of substrates, such as ATF2, MEF2C, MAX, CDC25B, and p53, underscoring its involvement in transcriptional adaptation, cell cycle regulation, and genotoxic stress responses. Several alternatively spliced transcript variants encode distinct MAPK14 isoforms.

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