AdipoUpX™ Human LIPC Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human LIPC Lentiviral Particle (Overexpression) is professionally engineered for the long-lasting, stable overexpression of the human LIPC gene. Hepatic lipase is critical for the remodeling of HDL and VLDL; this stable integration tool allows for the systematic investigation of lipid clearance and atherosclerosis risk. The product is ready-to-use and high-titer, with every lot passing rigorous quality control for titer, sterility, and purity. Our modular design offers high flexibility for the selection of tissue-specific promoters and reporter genes.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: LIPC

Full Name: Lipase C, hepatic type

Gene Symbol: HL; HTGL; LIPH; HDLCQ12

Gene ID: 3990

RefSeq ID-1: NP_000227.2

RefSeq ID-2: NM_000236.3

Summary: LIPC encodes Hepatic Lipase (HL), an enzyme with both phospholipase A1 and triacylglycerol lipase activity. This enzyme is located in the extracellular space, primarily on the surface of the liver and in the blood, where it plays a critical role in plasma lipoprotein particle remodeling and the catabolism of triglycerides and phospholipids. HL is central to cholesterol homeostasis by converting intermediate density lipoproteins (IDL) to low density lipoproteins (LDL). Abnormal LIPC activity is implicated in diseases like coronary artery disease and Type 2 diabetes, and it is a known biomarker of obesity and hyperinsulinism.

AdipoUpX™ Human LIPC Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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