AdipoUpX™ Human KSR2 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human KSR2 Lentiviral Particle (Overexpression) is a high-titer system for the specific and stable expression of the human KSR2 gene. As a scaffold protein for the Raf/MEK/ERK pathway, it is essential for researching the regulation of energy balance and thermogenesis. The lentivirus characteristic of genome integration establishes permanent cell models for long-term study. Clients can flexibly customize key functional components, including promoters and markers, while comprehensive quality control ensures both product safety and the highest experimental standards.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: KSR2

Full Name: Kinase suppressor of ras 2

Gene ID: 283455

RefSeq ID-1: NP_775869.3

RefSeq ID-2: NM_173598.4

Summary: KSR2 encodes a serine/threonine kinase scaffold protein involved in Ras-mediated signaling, calcium-dependent pathways, and regulation of cold-induced thermogenesis. It functions upstream of the MAPK cascade and is localized in the cytosol and plasma membrane. Variants in KSR2 can disrupt energy balance and thermogenic responses, contributing to obesity.

AdipoUpX™ Human KSR2 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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