AdipoUpX™ Human GHRL Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human GHRL Lentiviral Particle (Overexpression) is a professionally engineered vector particle providing efficient and long-lasting overexpression of human GHRL. As GHRL is the precursor for the Ghrelin appetite stimulant and central to the gut-brain axis, this stable integration system is an ideal tool for neuroendocrinology and appetite regulation research. It facilitates the investigation of its cleavage products and their role in hunger signaling. All viral particle products undergo comprehensive quality control to ensure safety and efficacy.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: GHRL

Full Name: Ghrelin and obestatin prepropeptide

Gene Symbol: MTLRP

Gene ID: 51738

RefSeq ID: NM_001134941.3, NP_001128413.1

Summary: The GHRL gene dictates the synthesis of a preproprotein that undergoes cleavage to release two hormones: ghrelin and obestatin. Ghrelin is known as the "hunger hormone," serving as a potent appetite stimulant secreted when the stomach is empty. It signals energy deficit by binding to the growth hormone secretagogue receptor (GHSR), initiating a cascade that promotes food-seeking behavior and growth hormone release. While obestatin was initially proposed as a satiety agent, current research points toward its involvement in regulating adipocyte function and glucose metabolism. GHRL is a critical component of the gut-brain axis controlling energy homeostasis and reward pathways.

AdipoUpX™ Human GHRL Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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