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AdipoUpX™ Human ADRB2 Lentiviral Particle (Overexpression)

Cat. No.: V1225XX422
Species: Human
Target Gene: ADRB2
Vector System: Lentiviral
Modulation Type: Overexpression
AdipoUpX™ Human ADRB2 Lentiviral Particle (Overexpression)
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Titer:
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Product Overview

Description: AdipoUpX™ Human ADRB2 Lentiviral Particle (Overexpression) is a powerful, high-titer gene delivery tool specifically designed for the long-lasting overexpression of the human ADRB2 gene. By enabling genome integration, this product allows researchers to establish stable cell lines for investigating catecholamine-induced lipolysis and energy expenditure. The system accelerates progress in metabolic research by allowing rapid validation of ADRB2 signaling in adipocytes. All viral particle products undergo comprehensive quality control to ensure both product safety and high efficacy.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.
Sterility Test: This product was certified sterile following successful microbial growth analysis.
Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.
Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.
Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.
Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.
Shipping Condition: Our lentivirus viral products are shipped using dry ice.
Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: ADRB2
Full Name: Adrenoceptor beta 2
Gene Symbol: BAR; ARB2; B2AR; ADRBR; ADRB2R; BETA2AR
Gene ID: 154
RefSeq ID-1: NP_000015.2
RefSeq ID-2: NM_000024.6
Summary: This gene encodes the beta-2-adrenergic receptor, a member of the G protein-coupled receptor superfamily. The receptor forms a signaling complex with its effector, the class C L-type calcium channel Ca(V)1.2, along with a G protein, adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase PP2A. This assembly allows precise and rapid signaling. ADRB2 also acts as a transcription regulator for the alpha-synuclein gene, with both genes linked to Parkinson’s disease risk. Being intronless, this gene has multiple polymorphic forms and mutations, which have been associated with nocturnal asthma, obesity, type 2 diabetes, and cardiovascular disease.

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