AdipoUpX™ Human INPPL1 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human INPPL1 Lentiviral Particle (Overexpression) is professionally engineered for the efficient and long-lasting overexpression of the human INPPL1 (SHIP2) gene. As a negative regulator of insulin signaling, this stable integration system is an ideal asset for researching the molecular triggers of Type 2 Diabetes. The lentivirus characteristics ensure the target gene establishes a reliable presence for longitudinal functional studies. Every viral batch undergoes comprehensive quality control screening (titer, sterility, and mycoplasma) to ensure the repeatability and safety of your experiments.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: INPPL1

Full Name: Inositol polyphosphate phosphatase like 1

Gene Symbol: OPSMD; SHIP2

Gene ID: 3636

RefSeq ID-1: NP_001558.3

RefSeq ID-2: NM_001567.3

Summary: INPPL1 encodes an SH2-domain-containing 5-inositol phosphatase that functions as a potent negative regulator of insulin signaling. By dephosphorylating phosphoinositide messengers, it attenuates the cellular response to insulin, contributing to the development of insulin resistance. Beyond its metabolic role, INPPL1 is involved in actin remodeling and serves as a significant biomarker for metastatic progression in various cancers.

AdipoUpX™ Human INPPL1 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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