LipoKnoxa™ Human SPX shRNA Lentiviral Particle (Silencing)

Sub Cat. No.	TargetSeq	Region	Inquiry
V0126XX605-1	CCTGGAAGACAGTCTGCTTAA	CDS	Inquiry
V0126XX605-2	CCGGAAAGACGAAGCCCAAAT	CDS	Inquiry
V0126XX605-3	GAACTGGACTCCTCAAGCTAT	CDS	Inquiry
V0126XX605-4	Other		Inquiry

Product Overview

Description: LipoKnoxa™ Human SPX shRNA Lentiviral Particle (Silencing) targets spexin, a neuropeptide with significant inhibitory effects on food intake and weight gain. By utilizing optimized U6 and miR30-based shRNA delivery, this tool assists in uncovering the pathways of the gut-brain axis. Our customizable lentiviral system supports flexible reporter gene inclusion and is verified via thorough QC validation, including high-sensitivity titer assays and sterility checks, to ensure high-fidelity research outcomes.

Production Cell Line: HEK293T

Promoter: U6; CMV; EF1α; CAG; UBC

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Comprehensive sequencing and PCR analyses were performed to verify the accurate genomic sequence of all viral preparations.

Sterility Test: Confirmed sterile via rigorous microbial analysis; free of bacterial and fungal contamination.

Mycoplasma Test: Rigorous quality control testing has confirmed the absence of mycoplasma contamination in this viral preparation.

Other QC: Customized supplementary testing and in vitro/in vivo assessments are available to verify post-silencing gene expression and biological functionality, ensuring the viral preparations meet the specific potency requirements of your gene interference project.

Storage: Store at -80°C for long-term preservation. Immediate transfer upon delivery is required to prevent loss of viral activity.

Stability: Shelf life: 6–12 months at -80°C (extended stability up to 2 years). Post-thaw: Stable at 4°C for 2–3 weeks without significant degradation of functional titers.

Shipping Condition: Products are delivered on dry ice to maintain the cold chain. Upon arrival, please ensure the presence of dry ice and transfer the vials immediately to -80°C storage.

Handling Notes: Avoid repeated freeze-thaw cycles. Aliquot into low-protein-binding tubes immediately after receipt to maintain optimal activity. For safety and contamination control, all viral handling must be performed inside a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: We ensure product integrity through rigorous QC, but we do not guarantee results in specific research contexts. Proper storage, handling, and total compliance with biosafety laws and safety protocols remain the sole responsibility of the user.

Target Profile

Gene Name: SPX

Full Name: Spexin hormone

Gene Symbol: SPX1; C12orf39

Gene ID: 80763

RefSeq ID-1: NP_085049.1

RefSeq ID-2: NM_030572.4

Summary: SPX is a peptide hormone that has emerged as a significant regulator of cardiovascular and renal functions. In metabolic research, Spexin has gained attention for its ability to induce weight loss and improve lipid profiles in animal models, suggesting it acts as a natural antagonist to the metabolic disruptions associated with obesity.

LipoKnoxa™ Human SPX shRNA Lentiviral Particle (Silencing)

Product Overview

Specification

Target Profile

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