AdipoUpX™ Human DYRK1B Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human DYRK1B Lentiviral Particle (Overexpression) is professionally engineered for the long-lasting, stable overexpression of the human DYRK1B gene. As a kinase implicated in abdominal obesity and metabolic syndrome, this stable integration tool facilitates systematic investigation into adipocyte differentiation and glucose metabolism. The product is ready-to-use and high-titer, with all particles undergoing rigorous internal quality control validation. Clients can freely customize functional components, including reporter genes and promoters, to meet their unique experimental needs.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: DYRK1B

Full Name: Dual specificity tyrosine phosphorylation regulated kinase 1B

Gene Symbol: MIRK; AOMS3

Gene ID: 9149

RefSeq ID-1: NP_004705.1

RefSeq ID-2: NM_004714.3

Summary: DYRK1B encodes a member of a nuclear-localized protein kinase family (DYRK). This enzyme participates in the critical regulation of the cell cycle and is involved in various signaling cascades. While its expression can be altered in certain tumor cells, its most notable clinical significance lies in metabolism: mutations in DYRK1B have been identified as a cause of Abdominal Obesity-Metabolic Syndrome 3. This links the kinase's role in cellular proliferation and differentiation directly to the development of central obesity and associated metabolic dysfunctions.

AdipoUpX™ Human DYRK1B Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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