AdipoUpX™ Human HMGCR Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human HMGCR Lentiviral Particle (Overexpression) is professionally engineered for the long-lasting, stable overexpression of the human HMGCR gene. As the rate-limiting enzyme in cholesterol biosynthesis, its stable integration is essential for researching lipid-lowering pathways and the molecular response to statins. The product is ready-to-use and high-titer, with every lot passing rigorous quality control for titer, sterility, and purity. Our modular design provides researchers with the ability to flexibly select labels for high-fidelity tracking of metabolic flux.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: HMGCR

Full Name: 3-Hydroxy-3-methylglutaryl-CoA reductase

Gene Symbol: MYPLG; LDLCQ3; LGMDR28

Gene ID: 3156

RefSeq ID-1: NP_000850.1

RefSeq ID-2: NM_000859.3

Summary: HMGCR encodes the rate-limiting enzyme in cholesterol biosynthesis. Controlling intracellular lipid levels, it influences energy metabolism and adipocyte lipid accumulation. Variants or pharmacologic modulation of HMGCR affect obesity-related metabolic traits. Alternative splicing generates multiple isoforms.

AdipoUpX™ Human HMGCR Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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