AdipoUpX™ Human CETP MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human CETP MMLV Particle (Overexpression) is a powerful gene delivery tool designed for the long-lasting overexpression of the human CETP gene. CETP facilitates the exchange of lipids between HDL and VLDL, playing a major role in atherosclerosis and metabolic syndrome. Because MMLV particles stably integrate into the genome of dividing cells, they enable the establishment of stable cell lines for drug discovery and lipid flux studies. Comprehensive quality control ensures the safety and efficacy of all viral products, allowing for rapid and reliable validation of protein function.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: CETP

Full Name: Cholesteryl ester transfer protein

Gene Symbol: BPIFF; HDLCQ10

Gene ID: 1071

RefSeq ID-1: NP_000069.2

RefSeq ID-2: NM_000078.3

Summary: CETP is a plasma protein that mediates the exchange of lipids between different lipoproteins. It primarily transfers cholesteryl esters from "good" HDL cholesterol to "bad" VLDL and LDL particles. Because high CETP activity lowers HDL levels, it is a major target in cardiovascular research. Genetic defects in CETP lead to elevated HDL levels, providing a protective effect against the heart disease often associated with obesity.

AdipoUpX™ Human CETP MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

Related Products