AdipoUpX™ Human BBS2 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human BBS2 Lentiviral Particle (Overexpression) is professionally engineered for the long-lasting, stable overexpression of the human BBS2 gene. This component of the BBSome is vital for investigating the ciliary mechanisms that regulate energy balance. The lentivirus characteristic of genome integration establishes reliable cell models for functional validation. The product is ready-to-use and high-titer, and all particles undergo comprehensive quality control (titer, sterility, and mycoplasma) to ensure experimental safety.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: BBS2

Full Name: Bardet-Biedl syndrome 2

Gene Symbol: BBS; RP74

Gene ID: 583

RefSeq ID-1: NP_001364385.1

RefSeq ID-2: NM_001377456.1

Summary: BBS2 is a member of the Bardet-Biedl syndrome (BBS) gene family, which is associated with an autosomal recessive disorder characterized by obesity, retinal dystrophy, polydactyly, renal anomalies, and cognitive impairment. BBS proteins are structurally diverse but share roles in cilia formation and function. Many localize to basal bodies, ciliary axonemes, and pericentriolar regions and participate in microtubule-dependent intracellular trafficking. BBS2 is a component of the BBSome complex with seven other BBS proteins.

AdipoUpX™ Human BBS2 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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