AdipoUpX™ Human ADRB3 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human ADRB3 Lentiviral Particle (Overexpression) is professionally engineered for the long-lasting, stable overexpression of the human ADRB3 gene. ADRB3 is the key receptor regulating lipolysis and adaptive thermogenesis in adipose tissue. This stable integration tool allows systematic investigation into ADRB3-mediated catecholamine signaling and energy expenditure. The product is ready-to-use, high-titer, and all particles undergo comprehensive quality control.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: ADRB3

Full Name: Adrenoceptor beta 3

Gene Symbol: BETA3AR

Gene ID: 155

RefSeq ID: NM_000025.3, NP_000016.1

Summary: The ADRB3 gene encodes the β-3 adrenergic receptor, a G protein-coupled receptor (GPCR) predominantly found on the surface of adipocytes (fat cells). This receptor acts as a primary transducer of catecholamine signals (like norepinephrine), initiating the downstream activation of adenylate cyclase. Physiologically, ADRB3 stimulation drives two critical energy-expending processes: lipolysis (breaking down stored fat) and thermogenesis (heat production). Polymorphisms within ADRB3 are frequently analyzed in human studies due to their correlation with individual variability in obesity susceptibility and overall metabolic rate.

AdipoUpX™ Human ADRB3 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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