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AdipoUpX™ Human ACSL1 Lentiviral Particle (Overexpression)

Cat. No.: V1225XX583
Species: Human
Target Gene: ACSL1
Vector System: Lentiviral
Modulation Type: Overexpression
AdipoUpX™ Human ACSL1 Lentiviral Particle (Overexpression)
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Product Overview

Description: AdipoUpX™ Human ACSL1 Lentiviral Particle (Overexpression) is professionally engineered for the efficient and long-lasting overexpression of the human ACSL1 gene. This is an essential tool for researching the activation of long-chain fatty acids for either oxidation or triglyceride synthesis in adipose and muscle tissues. Every batch is verified through comprehensive quality control screening (titer, sterility, and mycoplasma), ensuring that experimental results are repeatable and safe. The stable integration system allows for high-fidelity functional validation and long-term lipid flux analysis.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.
Sterility Test: This product was certified sterile following successful microbial growth analysis.
Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.
Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.
Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.
Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.
Shipping Condition: Our lentivirus viral products are shipped using dry ice.
Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: ACSL1
Full Name: Acyl-CoA synthetase long chain family member 1
Gene Symbol: ACS1; LACS; FACL1; FACL2; LACS1; LACS2
Gene ID: 2180
RefSeq ID-1: NP_001273637.1
RefSeq ID-2: NM_001286708.2
Summary: ACSL1 encodes a long-chain acyl-CoA synthetase isozyme that catalyzes the conversion of free long-chain fatty acids into fatty acyl-CoA esters. Although members of this enzyme family differ in substrate preference, tissue distribution, and subcellular localization, all play essential roles in lipid biosynthesis and fatty acid degradation. ACSL1 is highly relevant to obesity, as it regulates the balance between lipid storage and oxidation in metabolically active tissues such as adipose tissue, liver, and muscle. Dysregulation of ACSL1 activity can promote ectopic lipid accumulation and insulin resistance. Multiple alternatively spliced transcript variants have been described.

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