AdipoUpX™ Human ADCY3 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human ADCY3 Lentiviral Particle (Overexpression) is a professionally engineered vector particle providing efficient and long-lasting overexpression of the human ADCY3 gene. Localized to primary cilia, ADCY3 is central to cAMP-mediated satiety pathways; this stable integration system is an ideal tool for investigating ciliary signaling in obesity. Every batch is verified through comprehensive quality control screening for titer, sterility, and mycoplasma, ensuring the repeatability and safety of your metabolic experiments.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: ADCY3

Full Name: Adenylate cyclase 3

Gene Symbol: AC3; AC-III; BMIQ19

Gene ID: 109

RefSeq ID-1: NP_001307542.1

RefSeq ID-2: NM_001320613.1

Summary: ADCY3 encodes a membrane-associated enzyme that catalyzes the synthesis of the vital intracellular second messenger, cyclic adenosine monophosphate (cAMP), from ATP. This enzyme is widely distributed across various human tissues, including the brain and adipose tissue. Through its control over cAMP levels, ADCY3 is involved in numerous physiological and pathophysiological processes, including olfaction, neuronal function, and systemic metabolic regulation. Variations in this gene have been linked to appetite regulation and obesity susceptibility, highlighting its importance in metabolic signaling pathways.

AdipoUpX™ Human ADCY3 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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