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AdipoUpX™ Human ACLY Lentiviral Particle (Overexpression)

Cat. No.: V1225XX582
Species: Human
Target Gene: ACLY
Vector System: Lentiviral
Modulation Type: Overexpression
AdipoUpX™ Human ACLY Lentiviral Particle (Overexpression)
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Mammalian Cell Selection:
Fluorescent Reporters:
Titer:
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Product Overview

Description: AdipoUpX™ Human ACLY Lentiviral Particle (Overexpression) is a powerful, high-titer gene delivery tool specifically designed for the stable overexpression of the human ACLY gene. This enzyme is the primary link between carbohydrate metabolism and fatty acid synthesis; genome integration facilitates the creation of stable cell lines to investigate de novo lipogenesis. All viral particle products undergo rigorous internal quality control to ensure safety and efficacy. Our vector system features a modular design, allowing researchers to flexibly select reporter genes and promoters for precise metabolic tracking.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.
Sterility Test: This product was certified sterile following successful microbial growth analysis.
Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.
Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.
Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.
Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.
Shipping Condition: Our lentivirus viral products are shipped using dry ice.
Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: ACLY
Full Name: ATP citrate lyase
Gene Symbol: ACL; ATPCL; CLATP
Gene ID: 47
RefSeq ID-1: NP_001087.2
RefSeq ID-2: NM_001096.2
Summary: ACLY encodes ATP citrate lyase, the principal enzyme responsible for generating cytosolic acetyl-CoA from citrate in many tissues. This tetrameric enzyme catalyzes the ATP-dependent conversion of citrate and CoA into acetyl-CoA and oxaloacetate. Acetyl-CoA produced by ACLY serves as a central metabolic intermediate for lipogenesis and cholesterogenesis, processes that are often upregulated in obesity. In adipose tissue and liver, increased ACLY activity supports fatty acid synthesis and lipid accumulation, thereby contributing to weight gain and metabolic dysfunction. In nervous tissue, ACLY may also participate in acetylcholine biosynthesis. Multiple transcript variants encoding distinct isoforms have been identified.

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