Monkey pro-opiomelanocortin (POMC) ELISA kit (1.0-25 ng/mL)

Cat. No.: 0126WXX-1437

Assay Type: Quantitative sandwich ELISA

Target Species: Monkey

Assay Target: POMC

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Monkey pro-opiomelanocortin (POMC) ELISA kit (1.0-25 ng/mL)

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Product Overview

Description: Monkey pro-opiomelanocortin (POMC) ELISA kit (1.0-25 ng/mL) is an ELISA-based in vitro research tool designed specifically for the quantitative detection of POMC in monkey samples with a range of 1.0-25 ng/mL and a minimum detectable dose (sensitivity) of 0.1 ng/mL. The kit is highly sensitive and easy to use.

Assay Principle: The ELISA analytical biochemical technique is based on POMC antibody-POMC antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect POMC antigen targets in samples.

Background: POMC, a highly complex precursor polypeptide belonging to the POMC family and encoded at chromosomal location 2p23.3, serves as a central hub in the endocrine regulation of energy homeostasis and systemic metabolism. Synthesized as a secreted protein that undergoes extensive peptide hormone processing, POMC is vital for the neuropeptide signaling pathways that govern appetite regulation, glucose homeostasis, and blood pressure. Its biological significance is underscored by its role in producing ACTH to stimulate adrenal cortisol release, as well as its essential binding activities at melanocortin receptors (MC3R and MC4R) to modulate feeding behavior. Crucially, genetic defects in POMC are directly linked to Pro-opiomelanocortin Deficiency (POMCD) and a heightened susceptibility to early-onset obesity—a condition defined by the excessive accumulation of body fat beyond physiological requirements. Beyond its primary metabolic functions, POMC influences diverse processes ranging from cellular pigmentation and neuropeptide transduction to the negative regulation of tumor necrosis factor production, highlighting its status as a pivotal molecular driver in the complex pathology of metabolic disorders.

Synonyms: POC; NPP; ProOMC; ACTH; Pro-OMC; Pro opiomelanocortin; Corticotropin-lipotropin; Corticotropin; Adrenocorticotropic hormone; Proopiomelanocortin

Applications: Monkey pro-opiomelanocortin (POMC) ELISA kit (1.0-25 ng/mL) is used to quantify POMC in serum, plasma, cell culture supernatants, body fluid, tissue homogenate of monkey, providing data to support research in a wide range of areas, including endocrinology, obesity, and others.

Research Area: Endocrinology; Obesity

Specification

Sample Type: Serum; Plasma; Cell culture supernatants; Body fluid; Tissue homogenate

Detection Range: 1.0-25 ng/mL

Sensitivity: 0.1 ng/mL

Cross-reactivity: No significant cross-reactivity or interference was observed.

Storage: Store at 2-8°C.

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