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Vitamin B12 test kit

LipoKnoxa™ Human HSD11B1 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX248
Species: Human
Target Gene: HSD11B1
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human HSD11B1 shRNA AAV Particle (Silencing)
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX248-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CCTCCATCAGAAAGGAATATT CDS Inquiry
V0126XX248-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GAAGGAGTTCCTCTAACATTT 3' UTR Inquiry
V0126XX248-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle ATAGGTATAATTACCAGATAG 3' UTR Inquiry
V0126XX248-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CCTCCATCAGAAAGGAATATT CDS Inquiry
V0126XX248-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GAAGGAGTTCCTCTAACATTT 3' UTR Inquiry
V0126XX248-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle ATAGGTATAATTACCAGATAG 3' UTR Inquiry
V0126XX248-7 AAV3 Lung; Liver; Smooth muscle CCTCCATCAGAAAGGAATATT CDS Inquiry
V0126XX248-8 AAV3 Lung; Liver; Smooth muscle GAAGGAGTTCCTCTAACATTT 3' UTR Inquiry
V0126XX248-9 AAV3 Lung; Liver; Smooth muscle ATAGGTATAATTACCAGATAG 3' UTR Inquiry
V0126XX248-10 AAV4 CNS; Retina; Heart; Lung; Kidney CCTCCATCAGAAAGGAATATT CDS Inquiry
V0126XX248-11 AAV4 CNS; Retina; Heart; Lung; Kidney GAAGGAGTTCCTCTAACATTT 3' UTR Inquiry
V0126XX248-12 AAV4 CNS; Retina; Heart; Lung; Kidney ATAGGTATAATTACCAGATAG 3' UTR Inquiry
V0126XX248-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CCTCCATCAGAAAGGAATATT CDS Inquiry
V0126XX248-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GAAGGAGTTCCTCTAACATTT 3' UTR Inquiry
V0126XX248-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle ATAGGTATAATTACCAGATAG 3' UTR Inquiry
V0126XX248-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CCTCCATCAGAAAGGAATATT CDS Inquiry
V0126XX248-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GAAGGAGTTCCTCTAACATTT 3' UTR Inquiry
V0126XX248-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle ATAGGTATAATTACCAGATAG 3' UTR Inquiry
V0126XX248-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CCTCCATCAGAAAGGAATATT CDS Inquiry
V0126XX248-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GAAGGAGTTCCTCTAACATTT 3' UTR Inquiry
V0126XX248-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle ATAGGTATAATTACCAGATAG 3' UTR Inquiry
V0126XX248-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CCTCCATCAGAAAGGAATATT CDS Inquiry
V0126XX248-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GAAGGAGTTCCTCTAACATTT 3' UTR Inquiry
V0126XX248-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle ATAGGTATAATTACCAGATAG 3' UTR Inquiry
V0126XX248-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CCTCCATCAGAAAGGAATATT CDS Inquiry
V0126XX248-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GAAGGAGTTCCTCTAACATTT 3' UTR Inquiry
V0126XX248-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle ATAGGTATAATTACCAGATAG 3' UTR Inquiry
V0126XX248-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human HSD11B1 shRNA AAV Particle (Silencing) focuses on the inhibition of HSD11B1, the enzyme that regenerates active cortisol within metabolic tissues. Silencing this gene using our U6 or miR30 systems provides a unique method to study the role of local glucocorticoid excess in visceral obesity. A wide range of AAV serotypes is provided for optimal tissue tropism, supported by total quality control screening for functional titer, sequence integrity, and sterility.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: HSD11B1
Full Name: Hydroxysteroid 11-beta dehydrogenase 1
Gene Symbol: HDL; 11-DH; HSD11; HSD11B; HSD11L; CORTRD2; SDR26C1; 11-beta-HSD1
Gene ID: 3290
RefSeq ID-1: NP_001193670.1
RefSeq ID-2: NM_001206741.2
Summary: HSD11B1 is a microsomal enzyme that serves as a primary local regulator of the potent stress hormone, cortisol. In metabolic tissues (adipose, liver), the enzyme primarily acts as a reductase, catalyzing the conversion of the inactive metabolite cortisone back into the active cortisol. Overactivity of HSD11B1, resulting in excessive local cortisol regeneration, is a key molecular contributor to central obesity and subsequent metabolic syndrome. A specific common variant in this gene has been clearly associated with increased risk of obesity and insulin resistance in children. Deficiencies involving HSD11B1 and H6PD lead to cortisone reductase deficiency.

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