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AdipoUpX™ Human IL1B AAV Particle (Overexpression)
Cat. No.:
V1225XX281
Species:
Human
Target Gene:
IL1B
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX281-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX281-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX281-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX281-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX281-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX281-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX281-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX281-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX281-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX281-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human IL1B AAV Particle (Overexpression) is a ready-to-use gene delivery tool that has undergone rigorous quality control to ensure the stable overexpression of the human IL1B gene. As a key pro-inflammatory cytokine, it serves as a powerful asset for in-depth research into obesity-induced insulin resistance and chronic metabolic inflammation. Our AAV platform offers the benefit of high customization, allowing clients to flexibly select from multiple AAV serotypes and promoters, with comprehensive QC including titer, sterility, and mycoplasma testing to ensure the reproducibility and safety of your results.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
IL1B
Full Name:
Interleukin 1 beta
Gene Symbol:
IL-1; IL1F2; IL1beta; IL1-BETA
Gene ID:
3553
RefSeq ID-1:
NP_000567.1
RefSeq ID-2:
NM_000576.3
Summary:
IL1B is a foundational pro-inflammatory cytokine of the interleukin 1 family. It is synthesized by macrophages as an inactive precursor that requires proteolytic activation by caspase 1. As a primary mediator of the immune response, it influences cell growth and tissue remodeling. In the context of metabolic health, chronic IL1B signaling drives the low-grade systemic inflammation typically observed in obesity. It also plays a critical role in pulmonary damage during viral infections like COVID-19 and the pathogenesis of osteoarthritis.
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