Products
- Anti-Obesity Compound Library
- GPCR/G Protein-Targeted Compounds
- Immunology/Inflammation-Targeted Compounds
- JAK/STAT-Targeted Compounds
- MAPK-Targeted Compounds
- Membrane Transporter/Ion Channel-Targeted Compounds
- Metabolism-Targeted Compounds
- NF-κB-Targeted Compounds
- Microbiology/Virology-Targeted Compounds
- Neuronal Signaling-Targeted Compounds
- PI3K/Akt/mTOR-Targeted Compounds
- Oxidation-reduction-Targeted Compounds
- Proteases/Proteasome-Targeted Compounds
- Stem Cells/Wnt-Targeted Compounds
- Tyrosine Kinase/Adaptors-Targeted Compounds
- Ubiquitin-Targeted Compounds
Online Inquiry
AdipoUpX™ Human APOE AAV Particle (Overexpression)
Cat. No.:
V1225XX240
Species:
Human
Target Gene:
APOE
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
Add to basket
| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX240-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX240-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX240-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX240-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX240-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX240-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX240-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX240-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX240-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX240-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human APOE AAV Particle (Overexpression) is engineered for stable expression and functional signaling studies of the human APOE gene. It is essential for investigating triglyceride catabolism and cholesterol clearance in obesity research. Clients can freely select from multiple AAV serotypes and various fluorescent reporter genes to achieve precise targeted delivery and multifunctional tracking. Comprehensive quality control is also performed on all viral particle products to ensure experimental reproducibility and safety.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
APOE
Full Name:
Apolipoprotein E
Gene Symbol:
AD2; LPG; APO-E; ApoE4; LDLCQ5
Gene ID:
348
RefSeq ID-1:
NP_000032.1
RefSeq ID-2:
NM_000041.4
Summary:
APOE encodes a major apolipoprotein that is essential for the normal catabolism (breakdown and clearance) of triglyceride-rich lipoprotein remnants, particularly those derived from chylomicrons and VLDL. APOE binds to specific receptors on the liver and peripheral cells, acting as the recognition marker necessary for cellular uptake. The gene is located in a cluster on chromosome 19 with other related apolipoproteins (C1 and C2). Specific mutations in APOE result in familial dysbetalipoproteinemia (Type III hyperlipoproteinemia), a disorder characterized by the impaired clearance of these remnants, leading to elevated plasma cholesterol and triglyceride levels.
Related Products
-
AdipoUpX™ Human GHSR AAV Particle (Overexpression)
-
LipoKnoxa™ Human ADIPOR1 shRNA AAV Particle (Silencing)
-
LipoKnoxa™ Human ARL13B shRNA AAV Particle (Silencing)
-
AdipoUpX™ Human IFT74 AAV Particle (Overexpression)
-
AdipoUpX™ Human PLIN2 AAV Particle (Overexpression)
-
AdipoUpX™ Human ABCA1 AAV Particle (Overexpression)