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AdipoUpX™ Human TNMD AAV Particle (Overexpression)
Cat. No.:
V1225XX396
Species:
Human
Target Gene:
TNMD
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX396-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX396-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX396-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX396-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX396-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX396-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX396-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX396-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX396-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX396-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human TNMD AAV Particle (Overexpression) is a ready-to-use gene delivery tool that ensures the stable overexpression of the human TNMD gene. It serves as a reliable asset for investigating tissue remodeling and its link to central weight gain and metabolic dysfunction. Our AAV platform offers high customization for targeted delivery and tracking, while comprehensive QC—including titer, sterility, and mycoplasma testing—is performed to ensure research reliability.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
TNMD
Full Name:
Tenomodulin
Gene Symbol:
TEM; CHM1L; BRICD4
Gene ID:
64102
RefSeq ID-1:
NP_071427.2
RefSeq ID-2:
NM_022144.3
Summary:
TNMD encodes a protein structurally related to chondromodulin-I, a cartilage-associated glycoprotein that stimulates chondrocyte growth and inhibits endothelial tube formation. TNMD functions as an angiogenesis inhibitor and has been linked to the regulation of tissue vascularization. Genetic variants in TNMD are associated with central obesity, type 2 diabetes risk, and circulating immune mediator levels in a body size–dependent manner. The gene has also been proposed as a candidate for age-related macular degeneration.
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