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AdipoUpX™ Human OPA1 AAV Particle (Overexpression)
Cat. No.:
V1225XX347
Species:
Human
Target Gene:
OPA1
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX347-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX347-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX347-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX347-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX347-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX347-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX347-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX347-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX347-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX347-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human OPA1 AAV Particle (Overexpression) is a ready-to-use, high-titer AAV product that undergoes rigorous QC and ensures the efficient and stable expression of the human OPA1 gene. Specifically designed for validating OPA1’s role in mitochondrial inner membrane fusion and cristae maintenance, it serves as a reliable tool for accelerating bioenergetics and fat-burning research. Our customizable platform allows for the flexible selection of serotypes and fluorescent labels for precise targeted delivery.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
OPA1
Full Name:
OPA1 mitochondrial dynamin like GTPase
Gene Symbol:
NPG; NTG; MGM1; BERHS; largeG; MTDPS14
Gene ID:
4976
RefSeq ID-1:
NP_056375.2
RefSeq ID-2:
NM_015560.3
Summary:
OPA1 is a dynamin-related GTPase essential for maintaining mitochondrial stability and the integrity of the inner membrane. It regulates the energy output of the cell and manages the sequestration of cytochrome c to control programmed cell death. Mutations in OPA1 lead to optic atrophy, but its broader role in mitochondrial fusion is critical for overall metabolic health and efficient energy production.
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