AdipoUpX™ Human XBP1 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human XBP1 Lentiviral Particle (Overexpression) is professionally engineered for the efficient and long-lasting overexpression of the human XBP1 gene. This master regulator of the ER stress response is a reliable asset for researching the molecular triggers of insulin resistance and protein folding in metabolic tissues. Genome integration ensures the target gene establishes a permanent presence for longitudinal functional studies. Comprehensive quality control screening, including titer and purity testing, is performed on all viral products to ensure safety and data integrity.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: XBP1

Full Name: X-box binding protein 1

Gene Symbol: XBP2; TREB5; XBP-1; TREB-5

Gene ID: 7494

RefSeq ID-1: NP_001073007.1

RefSeq ID-2: NM_001079539.2

Summary: XBP1 is a bZIP transcription factor central to the endoplasmic reticulum (ER) stress response. Upon the accumulation of unfolded proteins, IRE1-mediated unconventional splicing converts XBP1 mRNA into its active form, XBP1(S). This activated factor drives the expression of chaperones to restore ER homeostasis, a pathway that is frequently impaired in obesity-linked liver dysfunction.

AdipoUpX™ Human XBP1 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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