AdipoUpX™ Human TMEM18 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human TMEM18 Lentiviral Particle (Overexpression) is professionally engineered for the long-lasting, stable overexpression of the human TMEM18 gene. Associated strongly with BMI and childhood obesity, this stable integration tool facilitates systematic investigation into its role in hypothalamic development and adipogenesis. The product is ready-to-use and high-titer, with all particles undergoing rigorous internal quality control validation (titer, sterility, and mycoplasma). Clients can freely customize markers and promoters to match their unique research models.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: TMEM18

Full Name: Transmembrane protein 18

Gene Symbol: lncND

Gene ID: 129787

RefSeq ID-1: NP_001339609.1

RefSeq ID-2: NM_001352680.2

Summary: TMEM18 is a nuclear membrane protein with DNA-binding capabilities that plays a significant role in cell migration. Despite its relatively small size, TMEM18 is one of the most powerful genetic loci identified in GWAS for Body Mass Index (BMI). While the precise molecular mechanism is still being elucidated, it is believed to act within the brain's neurodevelopmental centers to influence the long-term regulation of body weight.

AdipoUpX™ Human TMEM18 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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