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AdipoUpX™ Human FAS Lentiviral Particle (Overexpression)

Cat. No.: V1225XX587
Species: Human
Target Gene: FAS
Vector System: Lentiviral
Modulation Type: Overexpression
AdipoUpX™ Human FAS Lentiviral Particle (Overexpression)
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Product Overview

Description: AdipoUpX™ Human FAS Lentiviral Particle (Overexpression) is a powerful gene delivery tool specifically designed for the stable overexpression of the human FAS (FASN) gene. As the multi-enzyme system responsible for the final steps of fatty acid synthesis, its stable expression is an ideal tool for studying the metabolic triggers of fat accumulation. All viral products undergo rigorous internal quality control to ensure reliability and safety. Genome integration enables the establishment of stable cell lines for high-throughput screening of lipogenesis inhibitors.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.
Sterility Test: This product was certified sterile following successful microbial growth analysis.
Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.
Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.
Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.
Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.
Shipping Condition: Our lentivirus viral products are shipped using dry ice.
Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: FAS
Full Name: Fas cell surface death receptor
Gene Symbol: APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6
Gene ID: 355
RefSeq ID-1: NP_000034.1
RefSeq ID-2: NM_000043.6
Summary: FAS encodes a death receptor belonging to the TNF receptor superfamily and contains a cytoplasmic death domain essential for apoptosis signaling. Ligand binding triggers formation of the death-inducing signaling complex (DISC), involving FADD, caspase-8, and caspase-10, ultimately activating downstream caspase cascades. Beyond apoptosis, FAS signaling can activate NF-κB, ERK1, and JNK pathways, influencing cell proliferation. In obesity, dysregulated FAS-mediated apoptosis in adipocytes and immune cells contributes to adipose tissue remodeling, inflammation, and metabolic dysfunction. Multiple alternatively spliced transcript variants exist, including soluble isoforms that may inhibit apoptosis.

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