AdipoUpX™ Human STAT3 MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human STAT3 MSCV Particle (Overexpression) is a high-titer retroviral tool for the stable expression of signal transducer and activator of transcription 3. STAT3 is a primary mediator of leptin signaling in the hypothalamus, making this product vital for energy balance research. The MSCV system is optimized for stable, high-level expression in stem cells, hematopoietic stem cells, and diverse mammalian cell lines. Each batch is verified through rigorous quality control processes, including sterility and titer testing, ensuring a safe and effective platform for signaling research.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: STAT3

Full Name: Signal transducer and activator of transcription 3

Gene Symbol: APRF; HIES; ADMIO; ADMIO1

Gene ID: 6774

RefSeq ID-1: NP_001356441.1

RefSeq ID-2: NM_001369512.1

Summary: STAT3 encodes a transcription factor of the STAT family that responds to cytokines and growth factors. Upon phosphorylation, STAT3 dimerizes and translocates to the nucleus to regulate gene expression. It plays key roles in cell growth, apoptosis, and immune responses, including antiviral and antibacterial defense. Mutations are associated with infantile-onset multisystem autoimmune disease and hyper-IgE syndrome.

AdipoUpX™ Human STAT3 MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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