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AdipoUpX™ Human STAT1 Lentiviral Particle (Overexpression)

Cat. No.: V1225XX586
Species: Human
Target Gene: STAT1
Vector System: Lentiviral
Modulation Type: Overexpression
AdipoUpX™ Human STAT1 Lentiviral Particle (Overexpression)
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Mammalian Cell Selection:
Fluorescent Reporters:
Titer:
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Product Overview

Description: AdipoUpX™ Human STAT1 Lentiviral Particle (Overexpression) is a ready-to-use, high-titer vector particle designed for the efficient and stable overexpression of the human STAT1 gene. It serves as a powerful asset for researching interferon-mediated signaling and its role in adipocyte dysfunction during systemic inflammation. To ensure experimental reproducibility, every batch undergoes comprehensive quality control, including titer and mycoplasma testing. Our modular vector design offers high flexibility for the selection of reporter genes for precise signaling validation.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.
Sterility Test: This product was certified sterile following successful microbial growth analysis.
Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.
Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.
Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.
Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.
Shipping Condition: Our lentivirus viral products are shipped using dry ice.
Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: STAT1
Full Name: Signal transducer and activator of transcription 1
Gene Symbol: CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91
Gene ID: 6772
RefSeq ID-1: NP_009330.1
RefSeq ID-2: NM_007315.4
Summary: STAT1 encodes a signal transducer and activator of transcription that is activated by cytokines and growth factors, including interferons, EGF, PDGF, and IL6. Upon phosphorylation, STAT1 forms dimers that translocate to the nucleus and regulate gene expression involved in immune defense and cell survival. While STAT1 is essential for antiviral, antifungal, and antimycobacterial immunity, chronic STAT1 activation has been linked to inflammatory signaling pathways that can exacerbate obesity-related insulin resistance. Mutations in STAT1 are associated with Immunodeficiency 31A, 31B, and 31C.

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