AdipoUpX™ Human PTEN Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human PTEN Lentiviral Particle (Overexpression) is a powerful gene delivery tool specifically designed for the stable overexpression of the human PTEN gene. As a major negative regulator of the insulin signaling pathway, it is a reliable asset for studying metabolic resistance and cellular growth control. All viral particle products undergo comprehensive quality control to ensure safety and efficacy. Our customizable platform allows researchers to flexibly select reporter genes and promoters for precise targeted delivery and longitudinal tracking.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: PTEN

Full Name: Phosphatase and tensin homolog

Gene Symbol: BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; PTENbeta; PTENgama

Gene ID: 5728

RefSeq ID-1: NP_000305.3

RefSeq ID-2: NM_000314.6

Summary: PTEN encodes a phosphatase that dephosphorylates phosphoinositides, negatively regulating the AKT pathway and acting as a tumor suppressor. A longer mitochondrial-associated isoform may modulate energy metabolism. PTEN dysregulation can alter insulin signaling and cellular metabolism, contributing to obesity. Multiple transcript variants and translation start sites produce diverse isoforms.

AdipoUpX™ Human PTEN Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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