AdipoUpX™ Human PHIP MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human PHIP MMLV Particle (Overexpression) is a ready-to-use retroviral vector particle professionally engineered for the stable overexpression of the human PHIP gene. Facilitating the stable expression of this insulin receptor substrate ligand, it allows for in-depth research into its role as a modulator of the melanocortin pathway and glucose metabolism. All viral particle products undergo comprehensive quality control, including titer, sterility, and mycoplasma testing, to ensure experimental reliability and safety in dividing cell populations.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: PHIP

Full Name: PHIP subunit of CUL4-Ring ligase complex

Gene Symbol: ndrp; BRWD2; DIDOD; RepID; WDR11; DCAF14; CHUJANS

Gene ID: 55023

RefSeq ID-1: NP_060404.4

RefSeq ID-2: NM_017934.6

Summary: PHIP encodes an insulin–signaling–associated protein that interacts with insulin receptor substrate 1 and modulates glucose transporter trafficking in skeletal muscle cells. Beyond its metabolic role, PHIP may influence pancreatic beta-cell maintenance and survival. Alterations in the PHIP gene copy number and expression levels have also been correlated with melanoma progression, suggesting additional functions in cell growth and metastasis.

AdipoUpX™ Human PHIP MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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