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AdipoUpX™ Human BBS10 MMLV Particle (Overexpression)

Cat. No.: V1225XX636
Species: Human
Target Gene: BBS10
Vector System: MMLV Retrovirus
Modulation Type: Overexpression
AdipoUpX™ Human BBS10 MMLV Particle (Overexpression)
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Mammalian Cell Selection:
Fluorescent Reporters:
Titer:
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Product Overview

Description: AdipoUpX™ Human BBS10 MMLV Particle (Overexpression) is a high-titer, ready-to-use MMLV retroviral particle professionally engineered for the stable overexpression of the human BBS10 gene. This chaperonin-like protein is a frequent target for studying the primary causes of Bardet-Biedl Syndrome. Stable genomic integration in dividing cells provides a reliable platform for researching protein folding and ciliary signaling. Our vector platform supports flexible customization of reporter genes, and all products pass comprehensive quality control (titer, sterility, and mycoplasma testing).
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.
Sterility Test: The final viral preparation was confirmed sterile after testing.
Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.
Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.
Storage: The product must be immediately transferred to -80 °C storage upon its arrival.
Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.
Shipping Condition: Our MMLV retroviral products are shipped using dry ice.
Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: BBS10
Full Name: Bardet-Biedl syndrome 10
Gene Symbol: C12orf58
Gene ID: 79738
RefSeq ID-1: NP_078961.3
RefSeq ID-2: NM_024685.3
Summary: BBS10 is another member of the BBS gene family, strongly linked to BBS Type 10. Unlike many other BBS proteins, BBS10 does not appear to be a canonical ciliary structural protein but shows homology to type II chaperonins. It functions as a molecular chaperone, likely ensuring the correct folding or stability of other critical ciliary or basal body proteins. Inhibition of BBS10 expression directly impairs ciliogenesis in preadipocytes, reinforcing the link between this chaperone and the disease mechanism. Mutations in BBS10 cause BBS, characterized by progressive retinal degeneration, obesity, polydactyly, and renal issues.

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