AdipoUpX™ Human AGRP MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human AGRP MMLV Particle (Overexpression) is a powerful gene delivery tool designed for the stable overexpression of the human AGRP gene. As a potent orexigenic neuropeptide and MC4R antagonist, its stable expression is vital for studying hunger-driven behavior and energy conservation. The MMLV characteristics ensure the target gene establishes a permanent presence in the host cell line. Clients can customize promoters and labels, while comprehensive quality control is performed to ensure product safety and high-fidelity experimental results.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: AGRP

Full Name: Agouti related neuropeptide

Gene Symbol: ART; AGRT; ASIP2

Gene ID: 181

RefSeq ID-1: NP_001129.1

RefSeq ID-2: NM_001138.2

Summary: AGRP encodes agouti-related peptide, an endogenous antagonist of melanocortin-3 and melanocortin-4 receptors. It regulates hypothalamic control of feeding behavior through melanocortin receptor pathways and potentially via intracellular calcium signaling. By modulating appetite and energy balance, AGRP plays a key role in weight homeostasis. Mutations in this gene are associated with late-onset obesity, underlining its importance in long-term metabolic regulation.

AdipoUpX™ Human AGRP MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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