AdipoUpX™ Human ARL13B MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human ARL13B MMLV Particle (Overexpression) is a powerful gene delivery tool designed for the stable overexpression of the human ARL13B gene. It is a regulatory GTPase essential for ciliary structure and Shh signaling, both of which are central to metabolic health. Due to its stable integration into the genome, this MMLV particle is perfect for establishing stable ciliated cell models for obesity research. All viral products undergo comprehensive quality control validation to ensure high-fidelity performance and safety in genetic studies.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: ARL13B

Full Name: ARF like GTPase 13B

Gene Symbol: JBTS8; ARL2L1

Gene ID: 200894

RefSeq ID-1: NP_001167621.1

RefSeq ID-2: NM_001174150.2

Summary: ARL13B encodes a cilia-localized small GTPase required for ciliary structure and signaling. Primary cilia play a crucial role in hypothalamic pathways controlling appetite and energy expenditure, making ARL13B relevant to syndromic and monogenic obesity.

AdipoUpX™ Human ARL13B MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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