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AdipoUpX™ Human PCSK1 Lentiviral Particle (Overexpression)

Cat. No.: V1225XX402
Species: Human
Target Gene: PCSK1
Vector System: Lentiviral
Modulation Type: Overexpression
AdipoUpX™ Human PCSK1 Lentiviral Particle (Overexpression)
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Product Overview

Description: AdipoUpX™ Human PCSK1 Lentiviral Particle (Overexpression) is a powerful, high-titer gene delivery tool specifically designed for the stable overexpression of the human PCSK1 gene. This product is ideal for studying the proprotein convertase 1/3 enzyme's role in processing hormones like proinsulin and POMC. Genome integration ensures the creation of stable cell models, accelerating research into early-onset obesity. To ensure safety and efficacy, all particles undergo comprehensive quality control screening, and functional components can be flexibly customized to meet diverse needs.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.
Sterility Test: This product was certified sterile following successful microbial growth analysis.
Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.
Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.
Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.
Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.
Shipping Condition: Our lentivirus viral products are shipped using dry ice.
Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: PCSK1
Full Name: Proprotein convertase subtilisin/kexin type 1
Gene Symbol: PC1; PC3; NEC1; SPC3; PC1/3; BMIQ12
Gene ID: 5122
RefSeq ID-1: NP_000430.3
RefSeq ID-2: NM_000439.4
Summary: The PCSK1 gene codes for a member of the subtilisin-like proprotein convertase family (PC1/3), which are essential proteases for processing hormone and neuropeptide precursors within the secretory pathway. The resulting enzyme is activated within dense core secretory granules in the neuroendocrine system and brain. This protease cleaves its substrates at specific basic residue sites, generating mature, active polypeptide hormones and neuropeptides. Mutations in PCSK1 impair this activation process, leading to severe neuroendocrine disorders and a strong association with early-onset obesity and hormonal deficiencies.

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