AdipoUpX™ Human LPL Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human LPL Lentiviral Particle (Overexpression) is a high-titer system for the specific and long-lasting expression of the human LPL gene. Lipoprotein lipase is central to the clearance of triglycerides from the bloodstream; this stable integration system serves as an ideal tool for studying lipid partitioning between fat and muscle tissues. Clients can freely customize key functional components, such as fluorescent reporter genes and cell-specific promoters, to meet diverse experimental needs. Rigorous quality control is performed to ensure product safety and the reproducibility of results.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: LPL

Full Name: Lipoprotein lipase

Gene Symbol: LIPD; HDLCQ11

Gene ID: 4023

RefSeq ID-1: NP_000228.1

RefSeq ID-2: NM_000237.3

Summary: LPL encodes lipoprotein lipase, which is expressed in the heart, muscle, and adipose tissue. The protein functions as a homodimer, serving both as a triglyceride hydrolase and a ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations leading to LPL deficiency cause type I hyperlipoproteinemia, while milder mutations are associated with various disorders of lipid metabolism.

AdipoUpX™ Human LPL Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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