AdipoUpX™ Human ABCC8 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human ABCC8 Lentiviral Particle (Overexpression) is professionally engineered for the long-lasting, stable overexpression of the human ABCC8 (SUR1) gene. This subunit of the K-ATP channel is a critical tool for investigating insulin secretion and glucose-stimulated response mechanisms. This stable integration tool allows for the systematic investigation of beta-cell function in obesity. The product is ready-to-use and high-titer, and all particles undergo rigorous internal quality control validation to ensure reliability and safety.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: ABCC8

Full Name: ATP binding cassette subfamily C member 8

Gene Symbol: HI; SUR; HHF1; MRP8; PHHI; SUR1; ABC36; HRINS; PNDM3; TNDM2; MODY12; SUR1delta2

Gene ID: 6833

RefSeq ID-1: NP_000343.2

RefSeq ID-2: NM_000352.6

Summary: ABCC8 encodes a subunit of ATP-sensitive potassium channels that regulates insulin secretion from pancreatic β-cells. Mutations can cause hyperinsulinemic hypoglycemia of infancy or contribute to type 2 diabetes. Altered ABCC8 function affects insulin release and glucose homeostasis, linking it to obesity risk.

AdipoUpX™ Human ABCC8 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

Related Products