AdipoUpX™ Human MRAP2 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human MRAP2 Lentiviral Particle (Overexpression) is a powerful, high-titer gene delivery tool specifically designed for the stable overexpression of the human MRAP2 gene. This accessory protein is essential for the proper trafficking and signaling of MC4R in the hypothalamus. Genome integration enables the creation of stable cell models to study appetite regulation and obesity onset. Our vector system features a modular design for high customization, and all particles undergo comprehensive quality control to ensure product safety and efficacy.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: MRAP2

Full Name: Melanocortin 2 receptor accessory protein 2

Gene Symbol: C6orf117; bA51G5.2

Gene ID: 112609

RefSeq ID-1: NP_001333470.1

RefSeq ID-2: NM_001346541.1

Summary: MRAP2 encodes a protein that modulates melanocortin receptor signaling by regulating receptor trafficking and activation. Loss-of-function mutations in MRAP2 lead to severe obesity in mice and have been associated with extreme obesity in humans, indicating its key role in energy homeostasis.

AdipoUpX™ Human MRAP2 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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