LipoKnoxa™ Human PCSK1 shRNA Lentiviral Particle (Silencing)

Cat. No.: V0126XX432

Species: Human

Target Gene: PCSK1

Vector System: Lentiviral

Modulation Type: Silencing (shRNA)

LipoKnoxa™ Human PCSK1 shRNA Lentiviral Particle (Silencing)

INQUIRY Datasheet MSDS

Sub Cat. No.	TargetSeq	Region	Inquiry
V0126XX432-1	AGTGGAATCACACGGACATTT	CDS	Inquiry
V0126XX432-2	CTCTTACAGCAGCGGAGATTA	CDS	Inquiry
V0126XX432-3	TACGGGCAAAGGAGTTGTTAT	CDS	Inquiry
V0126XX432-4	Other		Inquiry

Product Overview

Description: LipoKnoxa™ Human PCSK1 shRNA Lentiviral Particle (Silencing) targets the proprotein convertase responsible for activating hormones like insulin and GLP-1. Engineered via our dual-strategy platform (U6 and miR30 systems), this lentiviral tool enables the stable dissection of endocrine processing defects. To ensure the highest level of biosafety, all products undergo total quality control screening, ensuring high functional titers and the absence of microbial contaminants.

Production Cell Line: HEK293T

Promoter: U6; CMV; EF1α; CAG; UBC

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Comprehensive sequencing and PCR analyses were performed to verify the accurate genomic sequence of all viral preparations.

Sterility Test: Confirmed sterile via rigorous microbial analysis; free of bacterial and fungal contamination.

Mycoplasma Test: Rigorous quality control testing has confirmed the absence of mycoplasma contamination in this viral preparation.

Other QC: Customized supplementary testing and in vitro/in vivo assessments are available to verify post-silencing gene expression and biological functionality, ensuring the viral preparations meet the specific potency requirements of your gene interference project.

Storage: Store at -80°C for long-term preservation. Immediate transfer upon delivery is required to prevent loss of viral activity.

Stability: Shelf life: 6–12 months at -80°C (extended stability up to 2 years). Post-thaw: Stable at 4°C for 2–3 weeks without significant degradation of functional titers.

Shipping Condition: Products are delivered on dry ice to maintain the cold chain. Upon arrival, please ensure the presence of dry ice and transfer the vials immediately to -80°C storage.

Handling Notes: Avoid repeated freeze-thaw cycles. Aliquot into low-protein-binding tubes immediately after receipt to maintain optimal activity. For safety and contamination control, all viral handling must be performed inside a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: We ensure product integrity through rigorous QC, but we do not guarantee results in specific research contexts. Proper storage, handling, and total compliance with biosafety laws and safety protocols remain the sole responsibility of the user.

Target Profile

Gene Name: PCSK1

Full Name: Proprotein convertase subtilisin/kexin type 1

Gene Symbol: PC1; PC3; NEC1; SPC3; PC1/3; BMIQ12

Gene ID: 5122

RefSeq ID-1: NP_000430.3

RefSeq ID-2: NM_000439.4

Summary: The PCSK1 gene codes for a member of the subtilisin-like proprotein convertase family (PC1/3), which are essential proteases for processing hormone and neuropeptide precursors within the secretory pathway. The resulting enzyme is activated within dense core secretory granules in the neuroendocrine system and brain. This protease cleaves its substrates at specific basic residue sites, generating mature, active polypeptide hormones and neuropeptides. Mutations in PCSK1 impair this activation process, leading to severe neuroendocrine disorders and a strong association with early-onset obesity and hormonal deficiencies.

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