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AdipoUpX™ Human IL13 Lentiviral Particle (Overexpression)

Cat. No.: V1225XX585
Species: Human
Target Gene: IL13
Vector System: Lentiviral
Modulation Type: Overexpression
AdipoUpX™ Human IL13 Lentiviral Particle (Overexpression)
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Product Overview

Description: AdipoUpX™ Human IL13 Lentiviral Particle (Overexpression) is professionally engineered for the long-lasting, stable overexpression of the human IL13 gene. This cytokine is critical for investigating the recruitment of M2-type macrophages and the maintenance of insulin sensitivity in adipose tissue. The product is ready-to-use and high-titer, with genome integration facilitating the creation of permanent cell models for anti-inflammatory research. All particles undergo rigorous internal quality control validation (titer, sterility, and mycoplasma) to ensure the highest experimental standards.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.
Sterility Test: This product was certified sterile following successful microbial growth analysis.
Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.
Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.
Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.
Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.
Shipping Condition: Our lentivirus viral products are shipped using dry ice.
Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: IL13
Full Name: Interleukin 13
Gene Symbol: P600; IL-13
Gene ID: 3596
RefSeq ID-1: NP_002179.2
RefSeq ID-2: NM_002188.2
Summary: IL13 encodes an immunoregulatory cytokine predominantly produced by activated Th2 cells. It plays multiple roles in B-cell maturation and differentiation, promotes IgE class switching, upregulates CD23 and MHC class II expression, and suppresses macrophage-derived pro-inflammatory cytokines and chemokines. IL13 is critical in allergen-induced asthma and functions independently of IgE and eosinophils. In the context of obesity, IL13 contributes to immune–metabolic crosstalk by modulating adipose tissue inflammation, which is a key driver of insulin resistance and metabolic dysfunction. IL13 is part of a cytokine gene cluster on chromosome 5q, located near IL4.

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