AdipoUpX™ Human IFT172 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human IFT172 Lentiviral Particle (Overexpression) is a high-titer system for the specific and stable expression of the human IFT172 gene. It is a critical tool for investigating intraflagellar transport and the structural basis of primary cilia in genetic obesity syndromes. Stable genomic integration ensures a reliable platform for researching the localization of metabolic receptors. Our vector system features a modular design for easy customization, and all products undergo comprehensive quality control to ensure experimental safety and the highest reproducibility of results.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: IFT172

Full Name: Intraflagellar transport 172

Gene Symbol: SLB; wim; RP71; BBS20; osm-1; NPHP17; SRTD10

Gene ID: 26160

RefSeq ID-1: NP_056477.1

RefSeq ID-2: NM_015662.3

Summary: IFT172 encodes a structural component of the intraflagellar transport B complex, which is essential for primary cilium formation and maintenance. Primary cilia serve as signaling hubs for pathways involved in energy balance and development. Disruption of IFT172 function is linked to ciliopathies that frequently present with metabolic abnormalities, including obesity.

AdipoUpX™ Human IFT172 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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