AdipoUpX™ Human ICAM1 MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human ICAM1 MMLV Particle (Overexpression) is a professionally engineered MMLV retroviral particle providing efficient and long-lasting overexpression of human ICAM1. This adhesion molecule is a critical marker for researching leukocyte infiltration in obese adipose tissue. Integrating into the host genome, it allows for the creation of stable cell lines for high-fidelity functional validation. To ensure experimental reliability, all particles undergo comprehensive quality control, including titer, sterility, and mycoplasma testing.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: ICAM1

Full Name: Intercellular adhesion molecule 1

Gene Symbol: BB2; CD54; P3.58

Gene ID: 3383

RefSeq ID-1: NP_000192.2

RefSeq ID-2: NM_000201.3

Summary: ICAM1 encodes a cell surface glycoprotein typically expressed on immune and endothelial cells, where it mediates leukocyte adhesion. It functions as a ligand for specific integrins and is notably utilized by certain viruses as an entry receptor. In the context of obesity, elevated ICAM1 levels often reflect the chronic vascular inflammation associated with metabolic syndrome.

AdipoUpX™ Human ICAM1 MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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